Sun Exposure = Mutations!
Remember to pack your sunscreen
Three paths to melanoma
The evolution to melanoma depends on the order in which pathogenic mutations accumulate.

Figure adapted from our 2020 Nature manuscript.
Evolution of cutaneous melanoma
The mutational landscapes of melanocytic neoplasms as they progress from the benign to the malignant state.

Figure adapted from: Shain et. al. NEJM (2015); Shain and Bastian, Nat Rev Cancer (2016)
Pathways disrupted
Signaling pathways become disrupted in a stereotypical fashion during the progression of cutaneous melanoma.

Figured adapted from Shain et. al. Cancer Cell 2018.
Evolution of uveal melanoma
The metastatic progression of melanomas originating in the eye.

Figure adapted from Shain et. al. Nature Genetics, 2019.
Genes involved in melanoma
A curated list of genes with pathogenic mutation in melanoma.

Figure adapted from Zeng, Judson-Torres, and Shain, JID, 2020.
Genes under selection in cSCC
A curated list of genes with pathogenic mutations in cSCC.

Figure adapted from our 2021 npj Genomic Medicine paper.

The Shain laboratory is located in the Department of Dermatology at the University of California San Francisco. We are currently looking to hire new postdocs. Please contact Hunter Shain to express interest or for more details ([email protected]).

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The overaching goal of the Shain laboratory is to better understand the biology of skin cancer. We use a variety of -omic approaches to delinate the genetic and transcriptomic alterations in melanocytic tissues. Recently, we have initiated single-cell based studies (both DNA- and RNA- single-cell sequencing). For more details related to ongoing projects, please reach out to the PI (Hunter Shain at [email protected]).