All Publications
A full list of publications can be retrieved from one of the following sources:
Featured First/Corresponding-author Publications
Chen L, Chang D, Tandukar B, Deivendran D, Pozniak J, Cruz-Pacheco N, Cho R, Cheng J, Yeh I, Marine C, Bastian BC, Ji AL, Shain AH. Visualizing somatic alterations in spatial transcriptomics data of skin cancer. BioRxiv. December 2022. Available Here.
Chang D, Shain AH. The landscape of driver mutations in cutaneous squamous cell carcinoma. npj Genomic Medicine. July 2021. Available Here.
- Featured by GlobalDermatologyTalks and Faculty Opinions. Study incorporated into cbioportal.
Tang J, Fewing, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan T, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH. The genomic landscapes of individual melanocytes from human skin. Nature. October 2020. Available Here.
- News and Views in Nature, Selected for Platform Presentation at the 2020 ASHG meeting, Profiled by U.S. News World Report and the UCSF Media Office, featured by JRNLclub and GlobalDermatologyTalks. Cited in WashingtonPost.
Shain AH*#, Bagger MM#, Yu R, Chang D, Liu S, Vemula S, Weier JF, Wadt K, Heegaard S, Bastian BC*, Kiilgaard JF*. The genetic evolution of metastatic uveal melanoma. Nature Genetics. July 2019. Available Here.
- Profiled by CureOM, presented at the EURETINA congress, recommended by F1000, and the American Academy of Ophthalmology
- *corresponding authors, #co-first authors
- Over 150 citations
Shain AH*, Joseph NM, Yu R, Benhamida J, Liu S, Prow T, Ruben B, North J, Pincus L, Yeh I, Judson R, Bastian BC*. Genomic and transcriptomic analysis reveal incremental disruption of key signaling pathways during melanoma evolution. Cancer Cell. July 2018. Available Here.
- Abstract selected to be part of the AACR Next Generation Stars of Cancer Research program
- Profiled by Cancer Cell, OncLive, CureToday ,and the UCSF media office
- *corresponding authors
- Over 100 citations
Shain AH, Bastian BC. From melanocytes to melanomas. Nature Reviews Cancer. June 2016. Available Here.
- Over 700 citations
Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian BC. The genetic evolution of melanoma from precursor lesions. The New England Journal of Medicine. November 2015. Available Here.
- Profiled by NBC News, PBS, Lancet, Cancer Discovery, ASCO, NEJM, Society of Melanoma Research, and the UCSF media office
- Over 900 citations
Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, Cho RJ, Murali R, Bastian BC. Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway. Nature Genetics. October 2015. Available Here.
- Profiled by Pigment Cell and Melanoma Research, Cancer Discovery, and the UCSF media office
- Over 200 citations
Shain AH, Pollack JR. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. PLoS One. January 2013. Available Here.
- Over 500 citations
Shain AH, Giacomini CP, Matsukuma K, Karikari CA, Bashyam MD, Hidalgo M, Maitra A, Pollack JR. Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. PNAS. January 2012. Available Here.
- Profiled by Nature India and The Stanford Daily
- Over 200 citations
Featured collaborative studies
Cao W, Lee H, Wu W, Zaman A, McCorkle S, Yan M, Chen J, Xing Q, Sinnott-Armstrong N, Xu H, Sailani MR, Tang W, Cui Y, Liu J, Guan H, Lv P, Sun X, Sun L, Han P, Lou Y, Chang J, Wang J, Gao Y, Guo J, Schenk G, Shain AH, Biddle FG, Collisson E, Synder M, Bivona TG. Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma. Nature Communications. July 2020.
Zeng H, Jorapur A, Shain AH, Lang UE, Torres R, Zhang Y, McNeal AS, Botton T, Lin J, Donne M, Bastian IN, Yu R, North JP, Pincus L, Ruben BS, Joseph NM, Yeh I, Bastian BC, Judson RL. Bi-allelic loss of CDKN2A initiates melanoma invasion via BRN2 activation. Cancer Cell. July 2018.
Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, Ryu J, Darzacq X, Bastian BC, Hockenmeyer D. Mutations in the promoter of telomerase gene TERT contribute to tumorigenesis by a two-step mechanism. Science. September 2017.
Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian BC, de la Fouchardiere A. Nature Communications. September 2017.
Yeh I, Botton T, Talevich E, Shain AH, Sparatta AJ, de la Fouchardiere A, Mully TW, North JP, Garrido MC, Gagnon A, Vemula SS, McCalmont TH, LeBoit PE, Bastian BC. Nature Communications. May 2015.
Funding
The Shain lab is grateful for the following sources of active funding: NIH National Cancer Institute (R01 CA265786), NIH NIAMS (AR080626), Department of Defense Melanoma Research Program, Melanoma Research Alliance, the LEO Foundation, and UCSF Department of Dermatology.
We also thank the following sources of former funding: American Cancer Society Research Scholar Grant, National Cancer Institute (K22 CA217997), Melanoma Research Foundation, American Federation of Aging Research, George and Judy Marcus Precision Medicine Fund, University of California Cancer Research Coordinating Committee, PhRMA Foundation, Dermatology Foundation, Mt. Zion Health Research Fund, UCSF Program in Breakthrough Biomedical Research, National Cancer Institute (T32 CA177555), National Science Foundation Graduate Fellowship Research Program, Stanford Graduate Fellows program